421 Cannot connect to SMTP server
You may get the following error message "’421 Cannot connect to SMTP server" in outlook and outlook express. Here I will post some of my opinions of this problem.
Error sample
"An unknown error has occurred. Account: ‘Hotmail’, Server: ‘smpt.live.com’, Protocol: SMTP, Server Response: ’421 Cannot connect to SMTP server 65.55.24.100 (65.55.24.100:25), connect error 10060′, Port: 25, Secure(SSL): Yes, Server Error: 421, Error Number: 0x800CCC67"
My opinions on fixing this problem
Please check your computer and make sure that the factors listed below are not affecting your ability to send messages. You may also contact your Internet Service Provider and verify if they are blocking Port 25.
a. You may be using the Incorrect SMTP settings.
b. Your firewall software is blocking your e-mail client or the port for outgoing messages (Port 25) is being blocked by your security software.
c. Your router has a firmware setting to block certain communication ports (specifically port 25).
d. Your ISP has blocked access to port 25.
I also suggest using port 587 instead of port 25. This will help you to get around any blocks set up on port 25.





Thanks for the article post.Really thank you! Awesome.
I have a mail server ocean , i had the problem conection with gmail or google only to send.
421 Cannot connect to SMTP server
led: Action=[SMTP Transfer], Details=[Domain=gmail.com, Host=alt4.gmail-smtp-in.l.google.com:25, IP=209.85.143.26: Transaction rejected with: 421 Cannot connect to SMTP server 209.85.143.26 (209.85.143.26:587), connect error 10060
i resolved that poweroff the avast in my server
am working with about 20 systems, my problems is that every 20 minutes i find myself restarting my modem or somtimes the router before mails can go out of my system, and anytime i try telneting is gives me an error message
421 Cannot connect to SMTP server , connect error 10061
please advice me and what to do.
Have you checked the several factors mentioned in this post?